Big YES and small no.
Depends on the environment it is in, the age of them when they get to become living singly and the type of fish. Like Ming said, we need huge tank for bigger fish to school.
Let say you keep a schooling fish singly and it preceives there is danger in the surroundings. It will stress. In general, schooling fish react to threats by sensing what everyones else is reacting. For example, the fish next to it move left, it will move left as well. The decision making of most schooling fish is as a whole without a hierarchy. If living singly, it does not have the same response from other fish anymore. The best way to respond to threat is to hide in a surrending where there is no changes. Over time the health of it decrease.