I have a picasso trigger with the following: flame angel, yellow tang, royal gramma, 2 percula clowns and 1 strawberry grouper. The inverts I have are a large hermit, several little bule legged guys, and various sizses of turbo snails. There has been at least one turbo disappearance from his shell. All crabs are still there. I think if the picasso is well fed, you will not have to worry too much about your fish. You will lose some inverts. If you feed it goldfish (NOT RECOMMENDED) you may have problems with fish of similar size. Stick with guppies, shrimp and plankton for food.
Several LFS have told me "it might work", but there are no guarantees.