Check for snails in the manifold ?
Could sound like there is air or something trapped in there, whats it ffeeding or is it return of some sort? What size is the pipe?? Looks like 1 inch?
Each of your manifolds is aiming down. It's possibles there is air trapped inside and just churning because bubbles want to go up and not down to exit the manifold. I would open the valve completely on the manifolds one by one to use the force of water to push the bubbles out. You might need to disconnect the reactors while doing that. The problem can arise again if the pump slowly accumulates bubbles again from micro bubbles or turning off the pump.